benzoic acid, 4-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-
4-[(tert-Butoxycarbonylamino)methyl]benzoic acid
CAS: 33233-67-9
Molecular Formula: C13H17NO4
benzoic acid, 4-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]- - Names and Identifiers
| Name | 4-[(tert-Butoxycarbonylamino)methyl]benzoic acid |
| Synonyms | BOC-PAMB BOC-PAMB-OH Boc-4-Amb-OH BOC-4-AMB-OH BOC-(4)AMBZ-OH BOC-HN-CH2-PH(4)-COOH BOC-P-AMINOMETHYLBENZOIC ACID BOC-(4-AMINOMETHYL)-BENZOIC ACID N-T-BUTOXYCARBONYL-4-AMINOMETHYLBENZOIC ACID 4-{[(tert-butoxycarbonyl)amino]methyl}benzoate 4-[(tert-Butoxycarbonylamino)methyl]benzoic acid 4-{[(tert-Butoxycarbonyl)amino]methyl}benzoic acid benzoic acid, 4-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]- |
| CAS | 33233-67-9 |
| InChI | InChI=1/C13H17NO4/c1-13(2,3)18-12(17)14-8-9-4-6-10(7-5-9)11(15)16/h4-7H,8H2,1-3H3,(H,14,17)(H,15,16)/p-1 |
benzoic acid, 4-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]- - Physico-chemical Properties
| Molecular Formula | C13H17NO4 |
| Molar Mass | 251.28 |
| Density | 1.178±0.06 g/cm3(Predicted) |
| Melting Point | 164-168°C |
| Boling Point | 427.8±38.0 °C(Predicted) |
| Flash Point | 212.6°C |
| Solubility | soluble in Methanol |
| Vapor Presure | 4.41E-08mmHg at 25°C |
| Appearance | Crystalline |
| Color | Off-white |
| BRN | 2854286 |
| pKa | 4.25±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
benzoic acid, 4-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]- - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| WGK Germany | 3 |
| HS Code | 29242990 |
| Hazard Class | IRRITANT |
benzoic acid, 4-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]- - Introduction
4-[(tert-Butoxycarbonylamino)methyl]benzoic acid is an organic compound with the chemical formula C13H17NO4.
Nature:
-Appearance: colorless crystal or white powder
-Melting Point: about 160-164 ℃
-Soluble: Slightly soluble in water, soluble in organic solvents such as ethanol and ether
-Stability: relatively stable at room temperature
Use:
4-[(tert-Butoxycarbonylamino)methyl]benzoic acid is commonly used as an intermediate and protecting group in organic synthesis, and has the following uses:
-as a raw material for the synthesis of cryptococcin
-for the synthesis of active molecules such as drugs, hormones and pesticides
-as a protecting group in the synthesis of chemicals
Method:
The preparation method of 4-[(tert-Butoxycarbonylamino)methyl]benzoic acid usually involves the following steps:
1. At a lower temperature, P-Toluic acid is reacted with 2,2,6,6-tetramethylpiperidine (TMEDA) in an organic solvent to generate a compound that is ready to be active.
2. The preparation of the active compound and tert-butyl alcohol ester will be reacted under alkaline conditions to generate the target product.
Safety Information:
4-[(tert-Butoxycarbonylamino)methyl]benzoic acid is a chemical and should be used in accordance with the following safety measures:
-Avoid direct contact with skin and eyes, and wear protective gloves and goggles when using.
-Please pay attention to a well-ventilated environment when using, avoid inhaling gas and solvent vapor.
-Avoid contact with oxidants and strong acids during storage, and keep away from fire and high temperature.
When using or handling this compound, refer to the relevant safety data sheet and operating instructions.
Nature:
-Appearance: colorless crystal or white powder
-Melting Point: about 160-164 ℃
-Soluble: Slightly soluble in water, soluble in organic solvents such as ethanol and ether
-Stability: relatively stable at room temperature
Use:
4-[(tert-Butoxycarbonylamino)methyl]benzoic acid is commonly used as an intermediate and protecting group in organic synthesis, and has the following uses:
-as a raw material for the synthesis of cryptococcin
-for the synthesis of active molecules such as drugs, hormones and pesticides
-as a protecting group in the synthesis of chemicals
Method:
The preparation method of 4-[(tert-Butoxycarbonylamino)methyl]benzoic acid usually involves the following steps:
1. At a lower temperature, P-Toluic acid is reacted with 2,2,6,6-tetramethylpiperidine (TMEDA) in an organic solvent to generate a compound that is ready to be active.
2. The preparation of the active compound and tert-butyl alcohol ester will be reacted under alkaline conditions to generate the target product.
Safety Information:
4-[(tert-Butoxycarbonylamino)methyl]benzoic acid is a chemical and should be used in accordance with the following safety measures:
-Avoid direct contact with skin and eyes, and wear protective gloves and goggles when using.
-Please pay attention to a well-ventilated environment when using, avoid inhaling gas and solvent vapor.
-Avoid contact with oxidants and strong acids during storage, and keep away from fire and high temperature.
When using or handling this compound, refer to the relevant safety data sheet and operating instructions.
Last Update：2024-04-09 15:17:56
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CAS: 33233-67-9
Tel: 18301782025
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Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: BOC-4-AMB-OH Request for quotationCAS: 33233-67-9
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